Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

Glutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.

Bibliographic Details
Main Authors: Linda Liedgens, Jannik Zimmermann, Lucas Wäschenbach, Fabian Geissel, Hugo Laporte, Holger Gohlke, Bruce Morgan, Marcel Deponte
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15441-3
id doaj-dde5ff42752f4627a0ede300208a59c0
record_format Article
spelling doaj-dde5ff42752f4627a0ede300208a59c02021-05-11T09:16:32ZengNature Publishing GroupNature Communications2041-17232020-04-0111111810.1038/s41467-020-15441-3Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxinsLinda Liedgens0Jannik Zimmermann1Lucas Wäschenbach2Fabian Geissel3Hugo Laporte4Holger Gohlke5Bruce Morgan6Marcel Deponte7Fachbereich Chemie, Abteilung Biochemie, Technische Universität KaiserslauternInstitut für Biochemie, Zentrum für Human- und Molekularbiologie (ZHMB), Universität des SaarlandesMathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität DüsseldorfFachbereich Chemie, Abteilung Biochemie, Technische Universität KaiserslauternInstitut für Biochemie, Zentrum für Human- und Molekularbiologie (ZHMB), Universität des SaarlandesMathematisch-Naturwissenschaftliche Fakultät, Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität DüsseldorfInstitut für Biochemie, Zentrum für Human- und Molekularbiologie (ZHMB), Universität des SaarlandesFachbereich Chemie, Abteilung Biochemie, Technische Universität KaiserslauternGlutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.https://doi.org/10.1038/s41467-020-15441-3
collection DOAJ
language English
format Article
sources DOAJ
author Linda Liedgens
Jannik Zimmermann
Lucas Wäschenbach
Fabian Geissel
Hugo Laporte
Holger Gohlke
Bruce Morgan
Marcel Deponte
spellingShingle Linda Liedgens
Jannik Zimmermann
Lucas Wäschenbach
Fabian Geissel
Hugo Laporte
Holger Gohlke
Bruce Morgan
Marcel Deponte
Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
Nature Communications
author_facet Linda Liedgens
Jannik Zimmermann
Lucas Wäschenbach
Fabian Geissel
Hugo Laporte
Holger Gohlke
Bruce Morgan
Marcel Deponte
author_sort Linda Liedgens
title Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
title_short Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
title_full Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
title_fullStr Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
title_full_unstemmed Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
title_sort quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description Glutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.
url https://doi.org/10.1038/s41467-020-15441-3
work_keys_str_mv AT lindaliedgens quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT jannikzimmermann quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT lucaswaschenbach quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT fabiangeissel quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT hugolaporte quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT holgergohlke quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT brucemorgan quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
AT marceldeponte quantitativeassessmentofthedeterminantstructuraldifferencesbetweenredoxactiveandinactiveglutaredoxins
_version_ 1721450151110770688

Similar Items