Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins
Glutaredoxins play a central role in numerous biological processes including cellular redox homeostasis and Fe-S cluster biogenesis. Here the authors establish the molecular basis for glutaredoxin redox catalysis through comprehensive biochemical and structural analyses.
Main Authors: | Linda Liedgens, Jannik Zimmermann, Lucas Wäschenbach, Fabian Geissel, Hugo Laporte, Holger Gohlke, Bruce Morgan, Marcel Deponte |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15441-3 |
Similar Items
-
Glutaredoxin catalysis requires two distinct glutathione interaction sites
by: Patricia Begas, et al.
Published: (2017-04-01) -
Glutaredoxin: Discovery, redox defense and much more
by: Fernando T. Ogata, et al.
Published: (2021-07-01) -
Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins
by: Daniel Trnka, et al.
Published: (2020-07-01) -
Aging-dependent changes in rat heart mitochondrial glutaredoxins—Implications for redox regulation
by: Xing-Huang Gao, et al.
Published: (2013-01-01) -
Redox Modulation Matters: Emerging Functions for Glutaredoxins in Plant Development and Stress Responses
by: Shutian Li
Published: (2014-11-01)