Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway

Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway

Promotion of apoptosis and suppression of proliferation in tumor cells are popular strategies for developing anticancer drugs. Sinomenine (SIN), a plant-derived alkaloid, displays antitumor activity. However, the mechanism of action of SIN against hepatocellular carcinoma (HCC) is unclear. Herein, s...

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Bibliographic Details
Main Authors: Wei Yang, Qihua Feng, Minjing Li, Jiaqi Su, Peiyuan Wang, Xu Wang, Yancun Yin, Xia Wang, Mingdong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
hepatocellular carcinoma
sinomenine
proliferation
AMPK
STAT3
MARCH1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.684262/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.684262/full

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