Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels

Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels

The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role in both physiology (control of memory formation, attention, working memory, and cognitive behavior) and pathophysiology (att...

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Bibliographic Details
Main Authors: Katarzyna Grzelka, Przemysław Kurowski, Maciej Gawlak, Paweł Szulczyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
pyramidal neurons
prefrontal cortex
adrenergic receptors
HCN channel
βγ subunit
membrane potential
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00341/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00341/full

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