Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome

Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome

Metabolic syndrome (MetS), which is associated with chronic inflammation, predisposes males to hypogonadism and subfertility. The underlying mechanism of these pathologies remains poorly understood. Homozygous leptin-resistant obese db/db mice are characterized by small testes, low testicular testos...

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Bibliographic Details
Main Authors: Qingkui Jiang, Constanze C. Maresch, Sebastian Friedrich Petry, Agnieszka Paradowska-Dogan, Sudhanshu Bhushan, Yongsheng Chang, Christine Wrenzycki, Hans-Christian Schuppe, Petr Houska, Michaela F. Hartmann, Stefan A. Wudy, Lanbo Shi, Thomas Linn
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-11-01
Series:JCI Insight
Subjects:
Endocrinology
Reproductive biology
Online Access:https://doi.org/10.1172/jci.insight.134882

Internet

https://doi.org/10.1172/jci.insight.134882

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