Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells

Pancreatic β-cells secrete insulin to lower blood glucose, following a meal. Maintenance of β-cell function is essential to preventing type 2 diabetes. In pancreatic β-cells, mitochondrial matrix calcium is an activating signal for insulin secretion. Recently, the molecula...

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Bibliographic Details
Main Authors: Flavien Bermont, Aurelie Hermant, Romy Benninga, Christian Chabert, Guillaume Jacot, Jaime Santo-Domingo, Marine R-C Kraus, Jerome N. Feige, Umberto De Marchi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Nutrients
Subjects:
mitochondria
calcium
insulin
polyphenols
β-cell
kaempferol
mitoxantrone
Online Access:https://www.mdpi.com/2072-6643/12/2/538

Internet

https://www.mdpi.com/2072-6643/12/2/538

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