A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in...

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Bibliographic Details
Main Authors: Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14029-w

Internet

https://doi.org/10.1038/s41467-019-14029-w

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