α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synucl...

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Bibliographic Details
Main Authors: Victor S. Van Laar, Jianming Chen, Alevtina D. Zharikov, Qing Bai, Roberto Di Maio, April A. Dukes, Teresa G. Hastings, Simon C. Watkins, J. Timothy Greenamyre, Claudette M. St Croix, Edward A. Burton
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Parkinson's disease
α-Synuclein
Peroxide
Glutathione
Zebrafish
Dopaminergic neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309009

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http://www.sciencedirect.com/science/article/pii/S2213231720309009

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