α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo
Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synucl...
Main Authors: | Victor S. Van Laar, Jianming Chen, Alevtina D. Zharikov, Qing Bai, Roberto Di Maio, April A. Dukes, Teresa G. Hastings, Simon C. Watkins, J. Timothy Greenamyre, Claudette M. St Croix, Edward A. Burton |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-10-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720309009 |
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