Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection

Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection

Bacterial superinfections are a primary cause of death during influenza pandemics and epidemics. Type I interferon (IFN) signaling contributes to increased susceptibility of mice to bacterial superinfection around day 7 post-influenza A virus (IAV) infection. Here we demonstrate that the reduced sus...

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Bibliographic Details
Main Authors: Kelly M. Shepardson, Kyle Larson, Rachelle V. Morton, Justin R. Prigge, Edward E. Schmidt, Victor C. Huber, Agnieszka Rynda-Apple
Format: Article
Language:English
Published: American Society for Microbiology 2016-05-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/3/e00506-16

Internet

http://mbio.asm.org/cgi/content/full/7/3/e00506-16

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