Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review

Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review

Biomarker-guided treatment is a rapidly developing area of medicine, where treatment choice is personalised according to one or more of an individual’s biomarker measurements. A number of biomarker-guided trial designs have been proposed in the past decade, including both adaptive and non-adaptive t...

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Bibliographic Details
Main Authors: Miranta Antoniou, Ruwanthi Kolamunnage-Dona, Andrea L. Jorgensen
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Journal of Personalized Medicine
Subjects:
biomarker-guided trial design
clinical research design
phase II
phase III
personalized medicine
predictive biomarker
prognostic biomarker
non-adaptive trial designs
clinical trials methodology
sample size
Online Access:http://www.mdpi.com/2075-4426/7/1/1

Internet

http://www.mdpi.com/2075-4426/7/1/1

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