Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

Recent studies have found that microRNA-29a (miR-29a) levels are significantly lower in fibrotic livers, as shown with human liver cirrhosis. Such downregulation influences the activation of hepatic stellate cells (HSC). Phosphoinositide 3-kinase p85 alpha (PI3KP85α) is implicated in the regulation...

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Bibliographic Details
Main Authors: Ya-Ling Yang, Feng-Sheng Wang, Hung-Yu Lin, Ying-Hsien Huang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
microRNA-29a
hepatitis
fibrosis
therapeutics
PI3KP85α
mitochondrial unfolded protein response
Online Access:https://www.mdpi.com/1422-0067/21/10/3636

Internet

https://www.mdpi.com/1422-0067/21/10/3636

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