Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra.

Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra.

BACKGROUND:Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown. There is a particular interest in investigating these effects in Parkinson disease wher...

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Bibliographic Details
Main Authors: Carlos Enrique Orozco-Barrios, Shyue-Fang Battaglia-Hsu, Martha Ligia Arango-Rodriguez, Jose Ayala-Davila, Celine Chery, Jean-Marc Alberto, Henry Schroeder, Jean-Luc Daval, Daniel Martinez-Fong, Jean-Louis Gueant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2791211?pdf=render

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http://europepmc.org/articles/PMC2791211?pdf=render

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