Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers

Olanzapine is an atypical antipsychotic widely used for the treatment of schizophrenia, which often causes serious adverse drug reactions. Currently, there are no clinical guidelines implementing pharmacogenetic information on olanzapine. Moreover, the Dutch Pharmacogenomics Working Group (DPWG) sta...

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Bibliographic Details
Main Authors: Pablo Zubiaur, Paula Soria-Chacartegui, Dora Koller, Marcos Navares-Gómez, Dolores Ochoa, Susana Almenara, Miriam Saiz-Rodríguez, Gina Mejía-Abril, Gonzalo Villapalos-García, Manuel Román, Samuel Martín-Vílchez, Francisco Abad-Santos
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Olanzapine
Pharmacogenetics
Precision medicine
Cytochrome P450
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312804

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http://www.sciencedirect.com/science/article/pii/S0753332220312804

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