Copy‐number analysis of Y‐linked loci in young men with non‐obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y

Copy‐number analysis of Y‐linked loci in young men with non‐obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y

Abstract Purpose Mosaic loss of chromosome Y (mLOY) is a common feature in elderly men. If mLOY can also occur in young men, it may lead to spermatogenic failure due to loss of spermatogenic genes. Indeed, previous studies detected the 45,X/46,XY karyotype in a few young men with spermatogenic failu...

Full description

Bibliographic Details
Main Authors: Erina Suzuki, Yoshitomo Kobori, Momori Katsumi, Kikumi Ushijima, Toru Uchiyama, Hiroshi Okada, Mami Miyado, Maki Fukami
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Reproductive Medicine and Biology
Subjects:
azoospermia
chromosome deletion
karyotype
sex chromosome
Y‐linked gene
Online Access:https://doi.org/10.1002/rmb2.12321

Internet

https://doi.org/10.1002/rmb2.12321

Similar Items