Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses

Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses

T-cell based vaccines against human immunodeficiency virus (HIV) generate specific responses that may limit both transmission and disease progression by controlling viral load. Broad, polyfunctional, and cytotoxic CD4+ T-cell responses have been associated with control of simian immunodeficiency vir...

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Bibliographic Details
Main Authors: Vinicius Canato Santana, Rafael Ribeiro Almeida, Susan Pereira Ribeiro, Luís Carlos de Souza Ferreira, Jorge Kalil, Daniela Santoro Rosa, Edecio Cunha Neto
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-01-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
granulocyte-macrophage colony-stimulating factor -
DNA vaccine
polyfunctional CD4+ T-cells
HIV
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015005025104&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015005025104&lng=en&tlng=en

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