The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart.

The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart.

Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...

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Bibliographic Details
Main Authors: Renata Windak, Julius Müller, Allison Felley, Alexander Akhmedov, Erwin F Wagner, Thierry Pedrazzini, Grzegorz Sumara, Romeo Ricci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769267?pdf=render

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http://europepmc.org/articles/PMC3769267?pdf=render

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