Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry

Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry

Melanoma is the most aggressive type of skin cancer due to its high capability of developing metastasis and acquiring chemoresistance. Altered redox homeostasis induced by increased reactive oxygen species is associated with melanomagenesis through modulation of redox signaling pathways. Dysfunction...

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Bibliographic Details
Main Authors: Fabiana Henriques Machado de Melo, Diego Assis Gonçalves, Ricardo Xisto de Sousa, Marcelo Yudi Icimoto, Denise de Castro Fernandes, Francisco R. M. Laurindo, Miriam Galvonas Jasiulionis
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
metastatic melanoma
eNOS uncoupling
tetrahydrobiopterin
L-sepiapterin
eNOS:BH4 stoichiometry
Online Access:https://www.mdpi.com/1422-0067/22/17/9556

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https://www.mdpi.com/1422-0067/22/17/9556

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