DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Bibliographic Details
Main Authors: Alison Howarth, Claire Simms, Nitesh Kerai, Olivia Allen, Karina Mihajluk, Patricia A. Madureira, Giannis Sokratous, Simon Cragg, Sang Y. Lee, Andy D. Morley, Keyoumars Ashkan, Paul A. Cox, Geoffrey J. Pilkington, Richard Hill
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319303274

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http://www.sciencedirect.com/science/article/pii/S1936523319303274

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