The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade through the effector kinases, Rad53 and Chk1, t...

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Bibliographic Details
Main Authors: Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski
Format: Article
Language:English
Published: Oxford University Press 2018-12-01
Series:G3: Genes, Genomes, Genetics
Subjects:
DNA Damage Response
checkpoint
Xrn1
Rad53
phosphoproteomics
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200767

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200767

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