Layer by Layer Assembled Chitosan-Coated Gold Nanoparticles for Enhanced siRNA Delivery and Silencing

Layer by Layer Assembled Chitosan-Coated Gold Nanoparticles for Enhanced siRNA Delivery and Silencing

Delivery of small interfering RNA (siRNA) provides one of the most powerful strategies for downregulation of therapeutic targets. Despite the widely explored capabilities of this strategy, intracellular delivery is hindered by a lack of carriers that have high stability, low toxicity and high transf...

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Bibliographic Details
Main Authors: Elnaz Shaabani, Maryam Sharifiaghdam, Herlinde De Keersmaecker, Riet De Rycke, Stefaan De Smedt, Reza Faridi-Majidi, Kevin Braeckmans, Juan C. Fraire
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
gold nanoparticles
Chitosan
layer by layer assembly
siRNA
gene delivery
endosomal escape
Online Access:https://www.mdpi.com/1422-0067/22/2/831

Internet

https://www.mdpi.com/1422-0067/22/2/831

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