Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring

Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring

Abstract There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment monitoring. RISK6 performance was also compared to that of two IGRAs: one based on RD1 antigens (QuantiFERON-TB G...

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Bibliographic Details
Main Authors: Rim Bayaa, Mame Diarra Bousso Ndiaye, Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu, Mohammad Khaja Mafij Uddin, Samanta Biswas, Rumana Nasrin, Paulo Ranaivomanana, Antso Hasina Raherinandrasana, Julio Rakotonirina, Voahangy Rasolofo, Giovanni Delogu, Flavio De Maio, Delia Goletti, Hubert Endtz, Florence Ader, Monzer Hamze, Mohamad Bachar Ismail, Stéphane Pouzol, Niaina Rakotosamimanana, Jonathan Hoffmann, The HINTT working group within the GABRIEL network
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93059-1

Internet

https://doi.org/10.1038/s41598-021-93059-1

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