Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes

Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes

Supplementation of micronutrients like folate is a double-edged sword in terms of their ambivalent role in cell metabolism. Although several epidemiological studies support a protective role of folate in carcinogenesis, there are also data arguing for an opposite effect. To address this issue in the...

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Bibliographic Details
Main Authors: Claudia Savini, Ruwen Yang, Larisa Savelyeva, Elke Göckel-Krzikalla, Agnes Hotz-Wagenblatt, Frank Westermann, Frank Rösl
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
human papillomavirus
anogenital cancer
karyotype
genomics
transcriptomics
micronutrients
Online Access:http://www.mdpi.com/1422-0067/20/5/1100

Internet

http://www.mdpi.com/1422-0067/20/5/1100

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