Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS). Other studies using knock-out (KO) mice have implicated nicotinic acetylcholine (AC...

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Bibliographic Details
Main Authors: Qiang Liu, Paul Whiteaker, Barbara J. Morley, Fu-Dong Shi, Ronald J. Lukas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
auto-immunity
cholinergic anti-inflammatory pathway
experimental autoimmune encephalomyelitis
inflammation
multiple sclerosis
nicotinic acetylcholine receptors
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00287/full

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00287/full

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