The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs

The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs

<b>Background:</b> Novel strategies to increase the efficacy of antiretroviral (ARV) drugs will be of crucial importance. We hypothesize that membranes of HIV-1-infected cells and enveloped HIV-1 particles may be preferentially targeted by the phytopeptide, cycloviolacin O2 (CyO2) to sig...

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Bibliographic Details
Main Authors: Samantha L. Gerlach, Partha K. Chandra, Upal Roy, Sunithi Gunasekera, Ulf Göransson, William C. Wimley, Stephen E. Braun, Debasis Mondal
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Medicines
Subjects:
cyclotides
cycloviolacin O2
CyO2
HIV-1
protease inhibitors
fusion inhibitors
antiretroviral drugs
Online Access:https://www.mdpi.com/2305-6320/6/1/33

Internet

https://www.mdpi.com/2305-6320/6/1/33

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