Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody

Taxanes are considered fundamental drugs in the treatment of breast cancer, but despite the similarities, docetaxel (doc) and paclitaxel (ptx) work differently. For this reason, it is interesting to identify mechanisms of antitumor activity of PAMAM dendrimer conjugates that carry docetaxel or pacli...

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Bibliographic Details
Main Authors: Monika Marcinkowska, Maciej Stanczyk, Anna Janaszewska, Arkadiusz Gajek, Malgorzata Ksiezak, Paula Dzialak, Barbara Klajnert-Maculewicz
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Polymers
Subjects:
trastuzumab
taxanes
tumour targeting
mitochondrial membrane potential
reactive oxygen species (ROS) formation
Online Access:https://www.mdpi.com/2073-4360/11/9/1422

Internet

https://www.mdpi.com/2073-4360/11/9/1422

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