The Phage T4 Antiholin RI Has a Cleavable Signal Peptide, Not a SAR Domain

The Phage T4 Antiholin RI Has a Cleavable Signal Peptide, Not a SAR Domain

Holin/endolysin-mediated lysis of phage T4 of Escherichia coli is tightly regulated by the antiholins RI and RIII. While regulation by the cytoplasmic RIII plays a minor role, the periplasmic antiholin RI binds tightly to the holin T and is believed to directly sense periplasmic phage DNA from super...

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Bibliographic Details
Main Authors: Denise Mehner-Breitfeld, Jan Michel Frederik Schwarzkopf, Ry Young, Kiran Kondabagil, Thomas Brüser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
phage lysis
holins
antiholins
lysis inhibition
signal peptide
SAR domain
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.712460/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.712460/full

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