Lack of airway submucosal glands impairs respiratory host defenses

Lack of airway submucosal glands impairs respiratory host defenses

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ec...

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Bibliographic Details
Main Authors: Lynda S Ostedgaard, Margaret P Price, Kristin M Whitworth, Mahmoud H Abou Alaiwa, Anthony J Fischer, Akshaya Warrier, Melissa Samuel, Lee D Spate, Patrick D Allen, Brieanna M Hilkin, Guillermo S Romano Ibarra, Miguel E Ortiz Bezara, Brian J Goodell, Steven E Mather, Linda S Powers, Mallory R Stroik, Nicholas D Gansemer, Camilla E Hippee, Keyan Zarei, J Adam Goeken, Thomas R Businga, Eric A Hoffman, David K Meyerholz, Randall S Prather, David A Stoltz, Michael J Welsh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
sus scrofa
host defense
lung
Online Access:https://elifesciences.org/articles/59653

Internet

https://elifesciences.org/articles/59653

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