Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites

Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites

Current strategies for regulatory control of gene expression are orthogonal to the host organism mechanisms. Here the authors demonstrate an RNA aptamer controlled system integrated into native regulatory pathways in the parasite Plasmodium falciparum.

Bibliographic Details
Main Authors: Suresh M. Ganesan, Alejandra Falla, Stephen J. Goldfless, Armiyaw S. Nasamu, Jacquin C. Niles
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10727
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spelling doaj-de4f9192e8bb4c6ba4ebcaac687eed222021-05-11T10:36:48ZengNature Publishing GroupNature Communications2041-17232016-03-017111010.1038/ncomms10727Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasitesSuresh M. Ganesan0Alejandra Falla1Stephen J. Goldfless2Armiyaw S. Nasamu3Jacquin C. Niles4Department of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biological Engineering, Massachusetts Institute of TechnologyCurrent strategies for regulatory control of gene expression are orthogonal to the host organism mechanisms. Here the authors demonstrate an RNA aptamer controlled system integrated into native regulatory pathways in the parasite Plasmodium falciparum.https://doi.org/10.1038/ncomms10727
collection DOAJ
language English
format Article
sources DOAJ
author Suresh M. Ganesan
Alejandra Falla
Stephen J. Goldfless
Armiyaw S. Nasamu
Jacquin C. Niles
spellingShingle Suresh M. Ganesan
Alejandra Falla
Stephen J. Goldfless
Armiyaw S. Nasamu
Jacquin C. Niles
Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
Nature Communications
author_facet Suresh M. Ganesan
Alejandra Falla
Stephen J. Goldfless
Armiyaw S. Nasamu
Jacquin C. Niles
author_sort Suresh M. Ganesan
title Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
title_short Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
title_full Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
title_fullStr Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
title_full_unstemmed Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
title_sort synthetic rna–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description Current strategies for regulatory control of gene expression are orthogonal to the host organism mechanisms. Here the authors demonstrate an RNA aptamer controlled system integrated into native regulatory pathways in the parasite Plasmodium falciparum.
url https://doi.org/10.1038/ncomms10727
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AT alejandrafalla syntheticrnaproteinmodulesintegratedwithnativetranslationmechanismstocontrolgeneexpressioninmalariaparasites
AT stephenjgoldfless syntheticrnaproteinmodulesintegratedwithnativetranslationmechanismstocontrolgeneexpressioninmalariaparasites
AT armiyawsnasamu syntheticrnaproteinmodulesintegratedwithnativetranslationmechanismstocontrolgeneexpressioninmalariaparasites
AT jacquincniles syntheticrnaproteinmodulesintegratedwithnativetranslationmechanismstocontrolgeneexpressioninmalariaparasites
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