Molecular Encapsulation of Histamine H2-Receptor Antagonists by Cucurbit[7]Uril: An Experimental and Computational Study

Molecular Encapsulation of Histamine H2-Receptor Antagonists by Cucurbit[7]Uril: An Experimental and Computational Study

The histamine H2-receptor antagonists cimetidine, famotidine and nizatidine are individually encapsulated by macrocyclic cucurbit[7]uril (CB[7]), with binding affinities of 6.57 (±0.19) × 103 M−1, 1.30 (±0.27) × 104 M−1 and 1.05 (±0.33) × 105 M−1, respectively. These 1:1 host-guest inclusion complex...

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Bibliographic Details
Main Authors: Hang Yin, Runmiao Wang, Jianbo Wan, Ying Zheng, Defang Ouyang, Ruibing Wang
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
cucurbit[7]uril
H2-receptor antagonists
molecular modelling
complexation
host-guest interaction
Online Access:http://www.mdpi.com/1420-3049/21/9/1178

Internet

http://www.mdpi.com/1420-3049/21/9/1178

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