Regulation of KCa2.3 and endothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes

Regulation of KCa2.3 and endothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes

Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium (KCa) channels specifically KCa2.3 and KCa3.1. Lipoxygenase (LOX) products function as endothelium-derived hyperpolarizing factors (EDHFs) i...

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Bibliographic Details
Main Authors: Kathryn M. Gauthier, William B. Campbell, Alister J. McNeish
Format: Article
Language:English
Published: PeerJ Inc. 2014-06-01
Series:PeerJ
Subjects:
Endothelium
Lipoxygensase
Isoprostane
Calcium-activated potassium channels
Nitric oxide
EDH
Online Access:https://peerj.com/articles/414.pdf

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https://peerj.com/articles/414.pdf

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