Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress

Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress

Psoriasis (PsO) is an autoimmune disease characterized by keratinocyte proliferation, chronic inflammation and mast cell activation. Up to 42% of patients with PsO may present psoriatic arthritis (PsA). PsO and PsA share common pathophysiological mechanisms: keratinocytes and fibroblast-like synovio...

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Bibliographic Details
Main Authors: Maria Sole Chimenti, Flavia Sunzini, Laura Fiorucci, Elisabetta Botti, Giulia Lavinia Fonti, Paola Conigliaro, Paola Triggianese, Luisa Costa, Francesco Caso, Alessandro Giunta, Maria Esposito, Luca Bianchi, Roberto Santucci, Roberto Perricone
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
psoriatic arthritis
psoriatic disease
autoimmunity
oxidative stress
apoptosis
cytochrome c and tryptase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02363/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02363/full

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