Correlation between infectivity and disease associated prion protein in the nervous system and selected edible tissues of naturally affected scrapie sheep.

The transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of a pathological form of a host protein known as prion protein (PrP). The validation of abnormal PrP detection techniques is fundamental to allow...

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Bibliographic Details
Main Authors: Francesca Chianini, Gian Mario Cosseddu, Philip Steele, Scott Hamilton, Jeremy Hawthorn, Sílvia Síso, Yvonne Pang, Jeanie Finlayson, Samantha L Eaton, Hugh W Reid, Mark P Dagleish, Michele Angelo Di Bari, Claudia D'Agostino, Umberto Agrimi, Linda Terry, Romolo Nonno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0122785