Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

Abstract Background As the primary immune response cell in the central nervous system, microglia constantly monitor the microenvironment and respond rapidly to stress, infection, and injury, making them important modulators of neuroinflammatory responses. In diseases such as Parkinson’s disease, Alz...

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Bibliographic Details
Main Authors: Kelly S. Kirkley, Katriana A. Popichak, Maryam F. Afzali, Marie E. Legare, Ronald B. Tjalkens
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Glial crosstalk
Manganism
NF-κB
Tumor necrosis factor
Online Access:http://link.springer.com/article/10.1186/s12974-017-0871-0

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http://link.springer.com/article/10.1186/s12974-017-0871-0

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