Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.

Bibliographic Details
Main Authors: Zita Sulyok, Rolf Fendel, Bianca Eder, Freia-Raphaella Lorenz, Natasha KC, Matthias Karnahl, Albert Lalremruata, The T. Nguyen, Jana Held, Folashade Almeine Cyntiche Adjadi, Torsten Klockenbring, Judith Flügge, Tamirat Gebru Woldearegai, Carlos Lamsfus Calle, Javier Ibáñez, Miriam Rodi, Diane Egger-Adam, Andrea Kreidenweiss, Carsten Köhler, Meral Esen, Mihály Sulyok, Anita Manoj, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Benjamin Mordmüller, Peter G. Kremsner
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22740-w

Internet

https://doi.org/10.1038/s41467-021-22740-w

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