Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22740-w |
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doaj-de6161831021472293648f15342062a52021-05-09T11:12:25ZengNature Publishing GroupNature Communications2041-17232021-05-0112111010.1038/s41467-021-22740-wHeterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trialZita Sulyok0Rolf Fendel1Bianca Eder2Freia-Raphaella Lorenz3Natasha KC4Matthias Karnahl5Albert Lalremruata6The T. Nguyen7Jana Held8Folashade Almeine Cyntiche Adjadi9Torsten Klockenbring10Judith Flügge11Tamirat Gebru Woldearegai12Carlos Lamsfus Calle13Javier Ibáñez14Miriam Rodi15Diane Egger-Adam16Andrea Kreidenweiss17Carsten Köhler18Meral Esen19Mihály Sulyok20Anita Manoj21Thomas L. Richie22B. Kim Lee Sim23Stephen L. Hoffman24Benjamin Mordmüller25Peter G. Kremsner26Institute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenSanaria IncInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenFraunhofer Institute of Molecular Biology and Applied Ecology IMEInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenSanaria IncSanaria IncSanaria IncSanaria IncInstitute of Tropical Medicine, University and University Hospital of TübingenInstitute of Tropical Medicine, University and University Hospital of TübingenIn this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.https://doi.org/10.1038/s41467-021-22740-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner |
| spellingShingle |
Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial Nature Communications |
| author_facet |
Zita Sulyok Rolf Fendel Bianca Eder Freia-Raphaella Lorenz Natasha KC Matthias Karnahl Albert Lalremruata The T. Nguyen Jana Held Folashade Almeine Cyntiche Adjadi Torsten Klockenbring Judith Flügge Tamirat Gebru Woldearegai Carlos Lamsfus Calle Javier Ibáñez Miriam Rodi Diane Egger-Adam Andrea Kreidenweiss Carsten Köhler Meral Esen Mihály Sulyok Anita Manoj Thomas L. Richie B. Kim Lee Sim Stephen L. Hoffman Benjamin Mordmüller Peter G. Kremsner |
| author_sort |
Zita Sulyok |
| title |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_short |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_full |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_fullStr |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_full_unstemmed |
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial |
| title_sort |
heterologous protection against malaria by a simple chemoattenuated pfspz vaccine regimen in a randomized trial |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies. |
| url |
https://doi.org/10.1038/s41467-021-22740-w |
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