Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial
In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.
Main Authors: | Zita Sulyok, Rolf Fendel, Bianca Eder, Freia-Raphaella Lorenz, Natasha KC, Matthias Karnahl, Albert Lalremruata, The T. Nguyen, Jana Held, Folashade Almeine Cyntiche Adjadi, Torsten Klockenbring, Judith Flügge, Tamirat Gebru Woldearegai, Carlos Lamsfus Calle, Javier Ibáñez, Miriam Rodi, Diane Egger-Adam, Andrea Kreidenweiss, Carsten Köhler, Meral Esen, Mihály Sulyok, Anita Manoj, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Benjamin Mordmüller, Peter G. Kremsner |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-22740-w |
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