Microtubules and their role in cellular stress in cancer

Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers, and are involved in cell movement, intracellular trafficking and mitosis. In the context of cancer, the tubulin family of proteins is recognized as the target of the tubulin-binding chemotherapeutics, which...

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Bibliographic Details
Main Authors: Joshua eMccarroll, Amelia eParker, Maria eKavallaris
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00153/full