Insights into the modulation of dopamine transporter function by amphetamine, orphenadrine and cocaine binding

Insights into the modulation of dopamine transporter function by amphetamine, orphenadrine and cocaine binding

Human dopamine transporter (hDAT) regulates dopaminergic signaling in the central nervous system by maintaining the synaptic concentration of dopamine (DA) at physiological levels, upon reuptake of DA into presynaptic terminals. DA translocation involves the co-transport of two sodium ions and the c...

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Bibliographic Details
Main Authors: Mary Hongying Cheng, Ethan eBlock, Feizhuo eHu, Murat Can Cobanoglu, Alexander eSorkin, Ivet eBahar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neurology
Subjects:
Amphetamine
Cocaine
Dopamine
Orphenadrine
human dopamine transporter
repurposable drugs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00134/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00134/full

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