Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

Abstract Proteins implicated in neurodegenerative conditions such as Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have been identified in bodily fluids encased in extracellular vesicles called exosomes. Whether exosomes found in DLB patients can transmit pathology is not clear. In th...

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Bibliographic Details
Main Authors: Jennifer Ngolab, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Margarita Trejo, Deborah Masliah, Anthony Adame, Eliezer Masliah, Robert A. Rissman
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Exosomes
Alpha synuclein
Lewy body
Tau
Amyloid beta
Online Access:http://link.springer.com/article/10.1186/s40478-017-0445-5

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http://link.springer.com/article/10.1186/s40478-017-0445-5

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