Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p

Temozolomide resistance in glioblastoma is associated with MGMT overexpression. Here, the authors identify a lncRNA that is a competitive endogenous RNA for miR-20b-3p, which causes c-Met activation to modulate acetylation of histone H3 on MGMT promoter through Stat3/p300 complex to increase MGMT ex...

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Bibliographic Details
Main Authors: Pengfei Wu, Jinquan Cai, Qun Chen, Bo Han, Xiangqi Meng, Yansheng Li, Ziwei Li, Ruijia Wang, Lin Lin, Chunbin Duan, Chunsheng Kang, Chuanlu Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10025-2

Internet

https://doi.org/10.1038/s41467-019-10025-2

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