Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies

Aberrantly activated Wnt signaling causes cellular transformation that can lead to human colorectal cancer. Wnt signaling is mediated by Lymphoid Enhancer Factor/T-Cell Factor (LEF/TCF) DNA-binding factors. Here we investigate whether altered <i>LEF</i>/<i>TCF</i> expression...

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Bibliographic Details
Main Authors: Claus-Dieter Mayer, Soizick Magon de La Giclais, Fozan Alsehly, Stefan Hoppler
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
Wnt
TCF
LEF
Online Access:https://www.mdpi.com/2073-4425/11/5/538