rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.

rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector.

BACKGROUND: BCG vaccination, combined with adenoviral-delivered boosts, represents a reasonable strategy to augment, broaden and prolong immune protection against tuberculosis (TB). We tested BCG (SSI1331) (in 6 animals, delivered intradermally) and a recombinant (rBCG) AFRO-1 expressing perfringoly...

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Bibliographic Details
Main Authors: Isabelle Magalhaes, Donata R Sizemore, Raija K Ahmed, Stefanie Mueller, Lena Wehlin, Charles Scanga, Frank Weichold, Giulia Schirru, Maria Grazia Pau, Jaap Goudsmit, Sharon Kühlmann-Berenzon, Mats Spångberg, Jan Andersson, Hans Gaines, Rigmor Thorstensson, Yasir A W Skeiky, Jerry Sadoff, Markus Maeurer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2582491?pdf=render

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http://europepmc.org/articles/PMC2582491?pdf=render

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