Blockade of JAK2 signaling produces immunomodulatory effect to preserve pancreatic homeostasis in severe acute pancreatitis

Blockade of JAK2 signaling produces immunomodulatory effect to preserve pancreatic homeostasis in severe acute pancreatitis

JAK/STAT plays an important role in cytokine signal transduction and it is potentially involved in the proinflammatory response during the early phase of severe acute pancreatitis (SAP). However, whether JAK2 activity is upregulated and whether JAK2 inhibition plays a role in the maintenance of panc...

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Bibliographic Details
Main Authors: Zhaolei Qiu, Feng Xu, Zhenjie Wang, Peng Yang, Zhang Bu, Feng Cheng, Hai Jiang, Lei Li, Fulong Zhang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
JAK-STAT
Pancreatitis
Immunomodulation
sTREM-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002272

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http://www.sciencedirect.com/science/article/pii/S2405580821002272

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