Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016

Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016

Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP). Hence, non-invasive imaging of this enzyme class...

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Bibliographic Details
Main Authors: Susann Schröder, Matthias Scheunemann, Barbara Wenzel, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
positron emission tomography
cyclic nucleotide phosphodiesterases
PDE inhibitors
PDE radioligands
radiochemistry
imaging
Online Access:https://www.mdpi.com/1422-0067/22/8/3832

Internet

https://www.mdpi.com/1422-0067/22/8/3832

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