Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1

Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1

TGF-β1 is a pleiotropic factor exerting a strong regulatory role in several cell types, including immune cells. In NK cells it profoundly alters the surface expression of crucial activating and chemokine receptors. To understand which soluble signals might better contrast these effects, we...

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Bibliographic Details
Main Authors: Beatrice Casu, Alessandra Dondero, Stefano Regis, Fabio Caliendo, Andrea Petretto, Martina Bartolucci, Francesca Bellora, Cristina Bottino, Roberta Castriconi
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
NK cells
TGF-β1
IL-18
cytokines
NKp30
activating receptors
CXCR4
chemokine receptors
p38MAPK
MEK/ERK
Online Access:http://www.mdpi.com/2072-6694/11/1/75

Internet

http://www.mdpi.com/2072-6694/11/1/75

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