IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice

IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice

Experimental infection with the protozoan parasite Leishmania major has been extensively used to understand the mechanisms involved in T helper cell differentiation. Following infection, C57BL/6 mice develop a small self-healing cutaneous lesion and they are able to control parasite burden, a proces...

Full description

Bibliographic Details
Main Authors: Marc Descatoire, Benjamin P. Hurrell, Melissa Govender, Katiuska Passelli, Berenice Martinez-Salazar, Ramona Hurdayal, Frank Brombacher, Reto Guler, Fabienne Tacchini-Cottier
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
Leishmania
IL-4
IL-4Rα
T helper cell differentiation
T helper 1
T helper 2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01265/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01265/full

Similar Items