The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-03-01
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Series: | Genes and Diseases |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304216300721 |