The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor...
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doaj-de756c5cb5334fb797303383bf0d18c82020-11-25T00:15:19ZengElsevierGenes and Diseases2352-30422017-03-0141192410.1016/j.gendis.2016.11.003The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolismXiu Lv0Jincheng Li1Chuhong Zhang2Tian Hu3Sai Li4Sha He5Hanxing Yan6Yixi Tan7Mingsheng Lei8Meiling Wen9Jianhong Zuo10The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaMedical School, Shaoyang University, Shaoyang, Hunan 422000, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaDepartment of Respiratory and Critical Care Medicine, Zhangjiajie City Hospital, Zhangjiajie, Hunan 427000, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaHypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.http://www.sciencedirect.com/science/article/pii/S2352304216300721AngiogenesisHIFHypoxiaMetabolismVHL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo |
spellingShingle |
Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism Genes and Diseases Angiogenesis HIF Hypoxia Metabolism VHL |
author_facet |
Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo |
author_sort |
Xiu Lv |
title |
The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
title_short |
The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
title_full |
The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
title_fullStr |
The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
title_full_unstemmed |
The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
title_sort |
role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism |
publisher |
Elsevier |
series |
Genes and Diseases |
issn |
2352-3042 |
publishDate |
2017-03-01 |
description |
Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer. |
topic |
Angiogenesis HIF Hypoxia Metabolism VHL |
url |
http://www.sciencedirect.com/science/article/pii/S2352304216300721 |
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