The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor...

Full description

Bibliographic Details
Main Authors:	Xiu Lv, Jincheng Li, Chuhong Zhang, Tian Hu, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo
Format:	Article
Language:	English
Published:	Elsevier 2017-03-01
Series:	Genes and Diseases
Subjects:	Angiogenesis HIF Hypoxia Metabolism VHL
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304216300721

id	doaj-de756c5cb5334fb797303383bf0d18c8
record_format	Article
spelling	doaj-de756c5cb5334fb797303383bf0d18c82020-11-25T00:15:19ZengElsevierGenes and Diseases2352-30422017-03-0141192410.1016/j.gendis.2016.11.003The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolismXiu Lv0Jincheng Li1Chuhong Zhang2Tian Hu3Sai Li4Sha He5Hanxing Yan6Yixi Tan7Mingsheng Lei8Meiling Wen9Jianhong Zuo10The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaMedical School, Shaoyang University, Shaoyang, Hunan 422000, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaDepartment of Respiratory and Critical Care Medicine, Zhangjiajie City Hospital, Zhangjiajie, Hunan 427000, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, ChinaHypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.http://www.sciencedirect.com/science/article/pii/S2352304216300721AngiogenesisHIFHypoxiaMetabolismVHL
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo
spellingShingle	Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism Genes and Diseases Angiogenesis HIF Hypoxia Metabolism VHL
author_facet	Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo
author_sort	Xiu Lv
title	The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
title_short	The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
title_full	The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
title_fullStr	The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
title_full_unstemmed	The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
title_sort	role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism
publisher	Elsevier
series	Genes and Diseases
issn	2352-3042
publishDate	2017-03-01
description	Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.
topic	Angiogenesis HIF Hypoxia Metabolism VHL
url	http://www.sciencedirect.com/science/article/pii/S2352304216300721
work_keys_str_mv	AT xiulv theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT jinchengli theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT chuhongzhang theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT tianhu theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT saili theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT shahe theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT hanxingyan theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT yixitan theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT mingshenglei theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT meilingwen theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT jianhongzuo theroleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT xiulv roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT jinchengli roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT chuhongzhang roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT tianhu roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT saili roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT shahe roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT hanxingyan roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT yixitan roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT mingshenglei roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT meilingwen roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism AT jianhongzuo roleofhypoxiainduciblefactorsintumorangiogenesisandcellmetabolism
_version_	1725387559484260352

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

Similar Items