DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton. DIAPH3 is essential for cytokinesis as its dysfunction impairs the contractile ring and produces multinucleated cells. Her...

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Bibliographic Details
Main Authors: Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
mDia2
malformation of cortical development
MTOC
Astrin
Online Access:https://elifesciences.org/articles/61974

Internet

https://elifesciences.org/articles/61974

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